Atomoxetine-Induced Increases in Monoamine Release in the Prefrontal Cortex are Similar in Spontaneously Hypertensive Rats and Wistar-Kyoto Rats

@article{Ago2014AtomoxetineInducedII,
  title={Atomoxetine-Induced Increases in Monoamine Release in the Prefrontal Cortex are Similar in Spontaneously Hypertensive Rats and Wistar-Kyoto Rats},
  author={Yukio Ago and Masato Umehara and Kosuke Higashino and Shigeru Hasebe and Kazumi Fujita and Kazuhiro Takuma and Toshio Matsuda},
  journal={Neurochemical Research},
  year={2014},
  volume={39},
  pages={825-832}
}
Spontaneously hypertensive rats (SHRs) are used as a model for attention-deficit/hyperactivity disorder (ADHD), since SHRs are hyperactive and show defective sustained attention in behavioral tasks. The psychostimulants amphetamine and methylphenidate and the selective norepinephrine reuptake inhibitor atomoxetine are used as ADHD medications. The effects of high K+ stimulation or psychostimulants on brain norepinephrine or dopamine release in SHRs have been previously studied both in vitro and… CONTINUE READING

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