Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat: A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

@article{Bymaster2002AtomoxetineIE,
  title={Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat: A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder},
  author={Frank P. Bymaster and Jason S. Katner and David L. Nelson and Susan K. Hemrick-Luecke and Penny G. Threlkeld and John Harrison Heiligenstein and Stephanie M. Morin and Donald R. Gehlert and Kenneth W. Perry},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={27},
  pages={699-711}
}
The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called tomoxetine or LY139603) has been shown to alleviate symptoms in Attention Deficit/Hyperactivity Disorder (ADHD). We investigated the mechanism of action of atomoxetine in ADHD by evaluating the interaction of atomoxetine with monoamine transporters, the effects on extracellular levels of monoamines, and the expression of the neuronal activity marker Fos in brain regions. Atomoxetine inhibited binding of… CONTINUE READING

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