Atomistic ensemble modeling and small-angle neutron scattering of intrinsically disordered protein complexes: applied to minichromosome maintenance protein.

@article{Krueger2011AtomisticEM,
  title={Atomistic ensemble modeling and small-angle neutron scattering of intrinsically disordered protein complexes: applied to minichromosome maintenance protein.},
  author={Susan Krueger and Joo-ho Shin and Sindhu Raghunandan and Joseph E. Curtis and Zvi Kelman},
  journal={Biophysical journal},
  year={2011},
  volume={101 12},
  pages={
          2999-3007
        }
}
The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea and eukarya. In this work we determined the solution structure of the N-terminal portion of the MCM complex from the archaeon Methanothermobacter thermautotrophicus (N-mtMCM) in the presence and absence of DNA using small-angle neutron scattering (SANS). N-mtMCM is a multimeric protein complex that consists of 12 monomers, each of which contains three distinct domains and two… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

References

Publications referenced by this paper.
Showing 1-10 of 32 references

The structure and function of MCM from archaeal M. thermoautotrophicum

  • R. J. Fletcher, B. E. Bishop, X. S. Chen
  • Nat. Struct. Biol
  • 2003
Highly Influential
8 Excerpts