Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum).

Abstract

The opium poppy (Papaver somniferum L.) is one of the oldest known medicinal plants. In the biosynthetic pathway for morphine and codeine, salutaridine is reduced to salutaridinol by salutaridine reductase (SalR; EC 1.1.1.248) using NADPH as coenzyme. Here, we report the atomic structure of SalR to a resolution of ∼1.9 Å in the presence of NADPH. The core… (More)
DOI: 10.1074/jbc.M110.168633

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