Atomic structure of anthrax protective antigen pore elucidates toxin translocation

Abstract

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Protective antigen forms oligomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and these pores translocate the enzymes… (More)
DOI: 10.1038/nature14247

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