Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase.

  title={Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase.},
  author={Hiroshi Nishimasu and Ryuichiro Ishitani and Koki Yamashita and Chikako Iwashita and Akira Hirata and Hiroyuki Hori and Osamu Nureki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 20},
tRNAs from all 3 phylogenetic domains have a 5-methyluridine at position 54 (T54) in the T-loop. The methyl group is transferred from S-adenosylmethionine by TrmA methyltransferase in most Gram-negative bacteria and some archaea and eukaryotes, whereas it is transferred from 5,10-methylenetetrahydrofolate (MTHF) by TrmFO, a folate/FAD-dependent methyltransferase, in most Gram-positive bacteria and some Gram-negative bacteria. However, the catalytic mechanism remains unclear, because the crystal… CONTINUE READING
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