Atomic structure and chemistry of human serum albumin

  title={Atomic structure and chemistry of human serum albumin},
  author={X. M. He and D. Carter},
  • X. M. He, D. Carter
  • Published 1992
  • Chemistry, Medicine
  • Nature
  • The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena… CONTINUE READING
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