Atomic structure and chemistry of human serum albumin

@article{He1992AtomicSA,
  title={Atomic structure and chemistry of human serum albumin},
  author={X. M. He and D. Carter},
  journal={Nature},
  year={1992},
  volume={358},
  pages={209-215}
}
  • X. M. He, D. Carter
  • Published 1992
  • Chemistry, Medicine
  • Nature
  • The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Three-dimensional structure of human serum albumin.
    • 478
    • PDF
    Evidence for the spontaneous formation of interspecies hybrid molecules of human, rat and bovine serum albumins.
    • 6
    Characterization, primary structure, and evolution of lamprey plasma albumin
    • J. Gray, R. Doolittle
    • Chemistry, Medicine
    • Protein science : a publication of the Protein Society
    • 1992
    • 45
    Effect of protein concentration on the binding of gold(I) to human serum albumin.
    • 15
    Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.
    • 171
    • PDF
    Production of recombinant human serum albumin from Saccharomyces cerevisiae
    • 35
    Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.
    • 128
    • PDF
    Nucleotide sequence of porcine liver albumin.
    • 43
    Primary structures of human alpha-fetoprotein and its mRNA.
    • 215
    • PDF