Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

@article{Cha1999AtomicSM,
  title={Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy},
  author={Albert Cha and Gregory E. Snyder and Paul R. Selvin and Francisco Bezanilla},
  journal={Nature},
  year={1999},
  volume={402},
  pages={809-813}
}
Voltage-gated ion channels are transmembrane proteins that are essential for nerve impulses and regulate ion flow across cell membranes in response to changes in membrane potential. They are made up of four homologous domains or subunits, each of which contains six transmembrane segments. Studies of potassium channels have shown that the second (S2) and fourth (S4) segments contain several charged residues, which sense changes in voltage and form part of the voltage sensor. Although these… Expand
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