Atomic mutagenesis at the ribosomal decoding site

  title={Atomic mutagenesis at the ribosomal decoding site},
  author={Pius Schrode and Paul Huter and Nina Clementi and Matthias David Erlacher},
  booktitle={RNA biology},
Ribosomal decoding is an essential process in every living cell. During protein synthesis the 30S ribosomal subunit needs to accomplish binding and accurate decoding of mRNAs. From mutational studies and high-resolution crystal structures nucleotides G530, A1492 and A1493 of the 16S rRNA came into focus as important elements for the decoding process. Recent crystallographic data challenged the so far accepted model for the decoding mechanism. To biochemically investigate decoding in greater… CONTINUE READING