Atomic model of the actin filament

@article{Holmes1990AtomicMO,
  title={Atomic model of the actin filament},
  author={K. Holmes and D. Popp and W. Gebhard and W. Kabsch},
  journal={Nature},
  year={1990},
  volume={347},
  pages={44-49}
}
The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. A unique orientation of the monomer with respect to the actin helix has been found. The main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand. There are also contacts along the left-handed genetic helix. 
The structure of the F-actin filament and the actin molecule.
The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin.
Two key questions raised by an atomic model for F-actin
Structure and dynamics of the actin filament.
Vibrational modes of G-actin.
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