Atomic-level characterization of disordered protein ensembles.

  title={Atomic-level characterization of disordered protein ensembles.},
  author={Tanja Mittag and Julie Deborah Forman-Kay},
  journal={Current opinion in structural biology},
  volume={17 1},
The roles of unfolded states of proteins in normal folding and in diseases involving aggregation, as well as the prevalence and regulatory functions of intrinsically disordered proteins, have become increasingly recognized. The structural representation of these disordered states as ensembles of interconverting conformers can therefore provide critical insights. Experimental methods can be used to probe ensemble-averaged structural properties of disordered states and computational approaches… CONTINUE READING

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