Atomic force microscopy study of the antigen-antibody binding force on patient cancer cells based on ROR1 fluorescence recognition.

@article{Li2013AtomicFM,
  title={Atomic force microscopy study of the antigen-antibody binding force on patient cancer cells based on ROR1 fluorescence recognition.},
  author={Mi Li and Xiubin Xiao and Lianqing Liu and Ning Xi and Yuechao Wang and Zaili Dong and Weijing Zhang},
  journal={Journal of molecular recognition : JMR},
  year={2013},
  volume={26 9},
  pages={
          432-8
        }
}
Knowledge of drug-target interaction is critical to our understanding of drug action and can help design better drugs. Due to the lack of adequate single-molecule techniques, the information of individual interactions between ligand-receptors is scarce until the advent of atomic force microscopy (AFM) that can be used to directly measure the individual ligand-receptor forces under near-physiological conditions by linking ligands onto the surface of the AFM tip and then obtaining force curves on… CONTINUE READING
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