Atomic force microscopic measurement of the interdomain angle in symmetric Holliday junctions.

@article{Sha2002AtomicFM,
  title={Atomic force microscopic measurement of the interdomain angle in symmetric Holliday junctions.},
  author={Ruojie Sha and Furong Liu and Nadrian C. Seeman},
  journal={Biochemistry},
  year={2002},
  volume={41 19},
  pages={5950-5}
}
The Holliday junction is a key intermediate in genetic recombination. It consists of four DNA strands that associate by base pairing to produce four double helices flanking a junction point. In the presence of multivalent cations, the four helices, in turn, stack in pairs to form two double-helical domains. The angle between these domains has been shown in a number of solution studies to be approximately 60 degrees in junctions flanked by asymmetric sequences. However, the recently determined… CONTINUE READING

Similar Papers

Loading similar papers…