Atomic basis of CRM1-cargo recognition, release and inhibition.

  title={Atomic basis of CRM1-cargo recognition, release and inhibition.},
  author={Ho Yee Joyce Fung and Yuh Min Chook},
  journal={Seminars in cancer biology},
CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug target as the transport receptor is overexpressed in many cancers where some of its cargos are misregulated and mislocalized to the cytoplasm. Atomic level understanding of CRM1 function has greatly facilitated recent drug discovery and development of CRM1 inhibitors to target a variety of malignancies. Numerous atomic… CONTINUE READING
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