Atomic Structure of the Y-Complex of the Nuclear Pore

  title={Atomic Structure of the Y-Complex of the Nuclear Pore},
  author={Kotaro Kelley and Kevin E. Knockenhauer and Greg Kabachinski and Thomas U Schwartz},
  booktitle={Nature Structural &Molecular Biology},
The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the >40-MDa ring-like structure. Here we present the 4.1-Å crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila… CONTINUE READING
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