Atomic Structure of T6SS Reveals Interlaced Array Essential to Function

@article{Clemens2015AtomicSO,
  title={Atomic Structure of T6SS Reveals Interlaced Array Essential to Function},
  author={Daniel L. Clemens and Peng Ge and B Y Lee and Marcus A. Horwitz and Z Hong Zhou},
  journal={Cell},
  year={2015},
  volume={160},
  pages={940-951}
}
Type VI secretion systems (T6SSs) are newly identified contractile nanomachines that translocate effector proteins across bacterial membranes. The Francisella pathogenicity island, required for bacterial phagosome escape, intracellular replication, and virulence, was presumed to encode a T6SS-like apparatus. Here, we experimentally confirm the identity of this T6SS and, by cryo electron microscopy (cryoEM), show the structure of its post-contraction sheath at 3.7 Å resolution. We demonstrate… CONTINUE READING
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