Atomic Resolution Insights into Curli Fiber Biogenesis

  title={Atomic Resolution Insights into Curli Fiber Biogenesis},
  author={Jonathan D. Taylor and Yizhou Zhou and Paula S Salgado and Ardan Patwardhan and Matt McGuffie and Tillmann Pape and Grzegorz J. Grabe and Elisabeth M Ashman and Sean C. Constable and Peter J. Simpson and Wei-chao Lee and Ernesto Cota and Matthew R Chapman and S. P. J. Matthews},
Bacteria produce functional amyloid fibers called curli in a controlled, noncytotoxic manner. These extracellular fimbriae enable biofilm formation and promote pathogenicity. Understanding curli biogenesis is important for appreciating microbial lifestyles and will offer clues as to how disease-associated human amyloid formation might be ameliorated. Proteins encoded by the curli specific genes (csgA-G) are required for curli production. We have determined the structure of CsgC and derived the… CONTINUE READING
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