Atomic Proximity between S4 Segment and Pore Domain in Shaker Potassium Channels

Abstract

A recently proposed model for voltage-dependent activation in K+ channels, largely influenced by the KvAP X-ray structure, suggests that S4 is located at the periphery of the channel and moves through the lipid bilayer upon depolarization. To investigate the physical distance between S4 and the pore domain in functional channels in a native membrane… (More)
DOI: 10.1016/S0896-6273(03)00468-9

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