Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

@article{Blundell1971AtomicPI,
  title={Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals},
  author={Tom L. Blundell and John F. Cutfield and Sue M Cutfield and Eleanor J. Dodson and Guy G. Dodson and Dorothy Mary Crowfoot Hodgkin and Dan Mercola and Mamannamana Vijayan},
  journal={Nature},
  year={1971},
  volume={231},
  pages={506-511}
}
Atomic positions in three dimensions have been derived for the two non-identical molecules of insulin in rhombohedral 2-zinc insulin crystals. Interesting correlations appear in their relation to the sequence variations observed so far in natural insulins. 

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X-ray analysis, circular dichroism, receptor binding and biological potencies of chemically modified insulins suggest that the conformation of the insulin molecule is critical to the formation of

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References

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Structure of Rhombohedral 2 Zinc Insulin Crystals

An electron density map has been calculated at a resolution of 2.8 Å which shows many details of the arrangement of the atoms in rhombohedral crystals of insulin.

The binding of transition metal ions in insulin crystals.

A mathematical model-building procedure for proteins

to be 0.112 A shorter than the sum of the Pauling covalent radii for carbon and sulphur. This bond must therefore possess considerable double-bond character. Cucka (1963) also puts forward an

Species variation in the amino acid sequence of insulin.

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