Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

@article{Blundell1971AtomicPI,
  title={Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals},
  author={Tom L. Blundell and John F. Cutfield and Sue M Cutfield and Eleanor J. Dodson and Guy G. Dodson and Dorothy Mary Crowfoot Hodgkin and Dan Mercola and Mamannamana Vijayan},
  journal={Nature},
  year={1971},
  volume={231},
  pages={506-511}
}
Atomic positions in three dimensions have been derived for the two non-identical molecules of insulin in rhombohedral 2-zinc insulin crystals. Interesting correlations appear in their relation to the sequence variations observed so far in natural insulins. 
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285 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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285 Citations

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Crystal structures of insulin contain molecules that are similar but not identical in conformation, which limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.
...

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