Atom-economical synthesis of functionalized cycloalkanes via catalytic redox cycloisomerization of propargyl alcohols.

Abstract

An atom-economical procedure for the direct synthesis of cycloalkanes from propargyl alcohols is reported. This high-yielding one-pot process involves a sequence consisting of a Ru-catalyzed redox isomerization of ynols into enones or an enal followed by an intramolecular Michael addition of a variety of carbon nucleophiles. Furthermore, an asymmetric… (More)
DOI: 10.1021/ol300278x

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@article{Trost2012AtomeconomicalSO, title={Atom-economical synthesis of functionalized cycloalkanes via catalytic redox cycloisomerization of propargyl alcohols.}, author={Barry M Trost and Alexander Breder and Bao Kai}, journal={Organic letters}, year={2012}, volume={14 7}, pages={1708-11} }