Atom-based pharmacophore modeling, CoMFA/CoMSIA-based 3D-QSAR studies and lead optimization of DPP-4 inhibitors for the treatment of type 2 diabetes

Abstract

A dipeptidyl peptidase-4 (DPP-4) enzyme is responsible for degradation of GLP-1 incretin hormone and in cooperates in glucose metabolism. Inhibition of DPP-4 is a promising new approach for the treatment of type-2 diabetes with low risk of hypoglycemia. An analog-based design study was performed using pharmacophore modeling and 3D-QSAR to design potential… (More)
DOI: 10.1007/s00044-014-0923-2

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@article{Jain2014AtombasedPM, title={Atom-based pharmacophore modeling, CoMFA/CoMSIA-based 3D-QSAR studies and lead optimization of DPP-4 inhibitors for the treatment of type 2 diabetes}, author={Shailesh V. Jain and Manjunath D. Ghate}, journal={Medicinal Chemistry Research}, year={2014}, volume={23}, pages={3436-3450} }