Atom-based 3D QSAR studies on novel N-β-d-xylosylindole derivatives as SGLT2 inhibitors

  title={Atom-based 3D QSAR studies on novel N-$\beta$-d-xylosylindole derivatives as SGLT2 inhibitors},
  author={Venkatesan Suryanarayanan and Arumugam Sudha and Sundararaj Rajamanikandan and Ramar Vanajothi and Pappu Srinivasan},
  journal={Medicinal Chemistry Research},
Sodium-dependent glucose cotransporter 2 (SGLT2) have emerged as a novel drug target for hyperglycemia, a major complication of type 2 diabetes, with a multitude of therapeutic potential for their inhibitors. A series of N-β-d-xylosylindole derivatives has been reported as SGLT2 inhibitors. Therefore, to determine the structural requisite of these SGLT2 inhibitors, 3D pharmacophore models and atom-based 3D QSAR models have been developed using the PHASE module of Schrödinger. The best six… 

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