Atoh7 promotes the differentiation of Müller cells-derived retinal stem cells into retinal ganglion cells in a rat model of glaucoma.

@article{Song2015Atoh7PT,
  title={Atoh7 promotes the differentiation of M{\"u}ller cells-derived retinal stem cells into retinal ganglion cells in a rat model of glaucoma.},
  author={WeiTao Song and Xue-yong Zhang and Xiaobo Xia},
  journal={Experimental biology and medicine},
  year={2015},
  volume={240 5},
  pages={682-90}
}
Glaucoma is one of the leading eye diseases resulting in blindness due to the death of retinal ganglion cells. This study aimed to develop novel protocol to promote the differentiation of retinal Müller cells into ganglion cells in vivo in a rat model of glaucoma. The stem cells dedifferentiated from rat retinal Müller cells were randomized to receive transfection with empty lentivirus PGC-FU-GFP or lentivirus PGC-FU-Atoh7-GFP, or no transfection. The stem cells were induced further to… CONTINUE READING