Atoh1 induces auditory hair cell recovery in mice after ototoxic injury.

@article{Kraft2013Atoh1IA,
  title={Atoh1 induces auditory hair cell recovery in mice after ototoxic injury.},
  author={Shannon M. Kraft and Chi Tung Hsu and D. Brough and Hinrich Staecker},
  journal={The Laryngoscope},
  year={2013},
  volume={123 4},
  pages={992-9}
}
OBJECTIVES/HYPOTHESIS To evaluate the ability of the Ad28.gfap.atoh1 to promote hair cell regeneration and hearing recovery in cochlea injured with kanamycin and furosemide. STUDY DESIGN In vivo model of hair cell ablation and subsequent treatment with Atoh1. METHODS The hair cells of C57BL/6 mice were ablated with systemic administration of kanamycin and furosemide. The left ears were treated with Ad28.gfap.atoh1. The right ears were not treated. Preablation audiograms and distortion… CONTINUE READING
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