Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.

@article{Soares1998AtmEP,
  title={Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.},
  author={Holly D Soares and J. I. Morgan and Peter J Mckinnon},
  journal={Neuroscience},
  year={1998},
  volume={86 4},
  pages={1045-54}
}
Ataxia-telangiectasia is a human autosomal recessive disease characterized by neurodegeneration, cancer predisposition and sensitivity to ionizing radiation. One of the earliest features of this disease is ataxia, which is thought to be attributable to a progressive cerebellar degeneration associated with a disruption of Purkinje cell cytoarchitecture and positioning. To investigate the neuropathology of ataxia-telangiectasia, we used in situ hybridization to map Atm (the gene mutated in ataxia… CONTINUE READING

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