Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.

@article{Moding2014AtmDW,
  title={Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.},
  author={Everett J Moding and Chang-Lung Lee and Katherine D. Castle and Patrick Oh and Lan Mao and Shan Zha and Hooney D. Min and Yan Ma and Shiva Das and David G. Kirsch},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 8},
  pages={
          3325-38
        }
}
Cells isolated from patients with ataxia telangiectasia are exquisitely sensitive to ionizing radiation. Kinase inhibitors of ATM, the gene mutated in ataxia telangiectasia, can sensitize tumor cells to radiation therapy, but concern that inhibiting ATM in normal tissues will also increase normal tissue toxicity from radiation has limited their clinical application. Endothelial cell damage can contribute to the development of long-term side effects after radiation therapy, but the role of… CONTINUE READING

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