Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.

@article{Chong2000AtmAB,
  title={Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.},
  author={Miriam J. Chong and Margaret R. Murray and Eric C. Gosink and Helen R C Russell and Anu Srinivasan and M. Kapsetaki and S Stanley J. Korsmeyer and Peter J Mckinnon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 2},
  pages={889-94}
}
Ataxia-telangiectasia is a hereditary multisystemic disease resulting from mutations of ataxia telangiectasia, mutated (ATM) and is characterized by neurodegeneration, cancer, immune defects, and hypersensitivity to ionizing radiation. The molecular details of ATM function in the nervous system are unclear, although the neurological lesion in ataxia-telangiectasia becomes apparent early in life, suggesting a developmental origin. The central nervous system (CNS) of Atm-null mice shows a… CONTINUE READING

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