• Corpus ID: 91287197

Atividades melanogênica, genotóxica e antiproliferativa de extratos de Brosimum gaudichaudii Trécul e Dorstenia brasiliensis Lam induzidas por radiação UVA.

  title={Atividades melanog{\^e}nica, genot{\'o}xica e antiproliferativa de extratos de Brosimum gaudichaudii Tr{\'e}cul e Dorstenia brasiliensis Lam induzidas por radiaç{\~a}o UVA.},
  author={Adriana Elias Pires Quevedo},
The linear furanocoumarins or psoralens are photosensitizers used in dermatology associated with ultraviolet A in the treatment of diseases such as vitiligo. Photochemotherapy has immediate adverse reactions (nausea, pruritus, erythema and xeroderma) and late (carcinogenesis and possibly cataracts). In Brazil, there are no medication or herbal products containing plant extracts for treatment of vitiligo that comply with current legislation of the National Agency for Sanitary Vigilance. The… 
Desenvolvimento, caracterização e avaliação in vitro de nanoemulsões o/a a partir de extratos de Brosimum gaudichaudii (Mama-cadela) como alternativa para o tratamento tópico de vitiligo
The nanoemulsions developed in this work were stable, with physical aspects and organoleptic characteristics suitable for topical application, and were able to concentrate the compounds on the skin, reducing the permeation through theskin, the That could cause a negative impact on the safety of vitiligo treatment.


Otimização das condições de extração hidroalcoólica das furanocumarinas de Dorstenia brasiliensis Lam. por maceração com ultra-som e análise quantitativa por CLAE/UV e fluorescência
Optimization of the conditions of hydroalcoholic extraction of furocoumarins from Dorstenia brasiliensis Lam. by maceration with sonication and quantitative analysis by HPLC/UV and fluorescence.
Percutaneous Penetration, Melanin Activation and Toxicity Evaluation of a Phytotherapic Formulation for Vitiligo Therapeutic
Photoacoustic depth monitoring showed that both formulations, with or without salicylic acid, propagated through the skin up to the melanocytes region, suggesting that the transport of the active agent may occur through the epithelial structure without the need of using queratinolitic substances, which are known to induce side effects in the animals.
Psoralen photobiology and photochemotherapy: 50 years of science and medicine.
Acute toxicity of Brosimum gaudichaudii Trécul. root extract in mice: determination of both approximate and median lethal doses
The Brosimum gaudichaudii Trecul (BG) Moraceae, with a high frequency in regions of the Brazilian cerrado (shrubland) and popularly known as "mamacadela", holds photosensitizing furocoumarins, a skin depigmentation disease that takes hold of approximately 1-2 % of the world population.
PUVA (5-methoxypsoralen plus UVA) enhances melanogenesis and modulates expression of melanogenic proteins in cultured melanocytes.
Results show that melanogenesis induced by PUVA is related to an increase in expression of tyrosinase, which suggests that PUVA favors the metabolic pathway of dark-eumelanins with high UV-protective properties.
Psoralens stimulate mouse melanocyte and melanoma tyrosinase activity in the absence of ultraviolet light.
It is demonstrated that psoralens activate processes within melanocytes resulting in both an immediate translocation of melanosomes within the cell (frog) or in a slower genomic event involving tyrosinase activation (melanoma cells) and eumelanin formation (mouse follicular melanocytes).
The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD.
Psoralen activity and binding sites in melanotic and amelanotic human melanoma cells.
Flow cytometry indicates that 8-MOP arrests the cells at the G0/G1 phase, irrespective of the presence or absence of UVA light, and it is noted that this compound elicits a biphasic cell response, since cell proliferation increases after the first 24-hr treatment, whereas it decreases in the subsequent 48 hr and thereafter.