Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells.

@article{Faderl2007AtiprimodBP,
  title={Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells.},
  author={Stefan J Faderl and Alessandra Ferrajoli and David Harris and Quin Van and Hagop M Kantarjian and Zeev Estrov},
  journal={Leukemia research},
  year={2007},
  volume={31 1},
  pages={91-5}
}
In studies of multiple myeloma cells, atiprimod was shown to block Stat3 activation and inhibited colony-forming cell proliferation. We hypothesized that atiprimod may also inhibit activation of intracellular signaling pathways in AML cells resulting in apoptosis and growth inhibition. We demonstrate that atiprimod inhibited clonogenic growth of AML cell lines and fresh AML marrow cells whereas it did not significantly affect growth of normal hematopoietic progenitors from marrow samples of… CONTINUE READING

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