Atioxidative protection by melatonin

@article{Hardeland2007AtioxidativePB,
  title={Atioxidative protection by melatonin},
  author={R{\"u}diger Hardeland},
  journal={Endocrine},
  year={2007},
  volume={27},
  pages={119-130}
}
Melatonin has been shown to protect against oxidative stress in various, highly divergent experimental systems. There are many reasons for its remarkable protective potential. Signaling effects comprise the upregulation of antioxidant enzymes, such as superoxide dismutases, peroxidases, and enzymes of glutathione supply, downregulation of prooxidant enzymes, such as nitric oxide synthases and lipoxygenases, and presumably also the control of quinone reductase 2. Other mechanisms are based on… 
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