Atioxidative protection by melatonin

  title={Atioxidative protection by melatonin},
  author={R{\"u}diger Hardeland},
Melatonin has been shown to protect against oxidative stress in various, highly divergent experimental systems. There are many reasons for its remarkable protective potential. Signaling effects comprise the upregulation of antioxidant enzymes, such as superoxide dismutases, peroxidases, and enzymes of glutathione supply, downregulation of prooxidant enzymes, such as nitric oxide synthases and lipoxygenases, and presumably also the control of quinone reductase 2. Other mechanisms are based on… 
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Melatonin's family is rather exceptional, offering versatile and collective antioxidant protection against OS, and it certainly seems that melatonin is one of nature's defenses against oxidative damage.
Computer-designed melatonin derivatives: potent peroxyl radical scavengers with no pro-oxidant behavior
The gathered data indicate that while melatonin itself is not a good peroxyl radical scavenger, functionalizing its molecular framework may produce derivatives that excellent for that purpose.
Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats
Results indicate that melatonin prevents nephrotoxicity induced by GM in rats, presumably because it is a potent antioxidant, restores antioxidant enzyme activity, and blocks NF-κB and iNOS activation in rat kidney.
Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans
Given that dietary melatonin is absorbed in the gastrointestinal tract and transported into the bloodstream, the ingestion of medicinal and plant foods by mammals as a source of melatonin may be conceived as a key step in serum melatonin modulation and, consequently, health promotion.
Melatonin improves adriamycin-induced hepatic oxidative damage in rats
Results indicated that MLT improved the oxidative damage induced by ADR in rat liver, presumably due to its ability to inhibit lipid peroxidation, and restore both enzymatic and nonenzymatic antioxidant activities.
Assessment of exogenous melatonin action on mouse liver cells after exposure to soman.
Melatonin Receptor Agonist Ramelteon Reduces Ischemia-Reperfusion Injury Through Activation of Mitochondrial Potassium Channels
This study shows for the first time that ramelteon induces cardioprotection through melatonin receptor; the effect is not concentration-dependent; and activation of mKCa and mKATP channels is involved.


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