Athyroid Pax 8 / Mice Cannot Be Rescued by the Inactivation of Thyroid Hormone Receptor 1

Abstract

The Pax8 / mouse provides an ideal animal model to study the consequences of congenital hypothyroidism, because its only known defect is the absence of thyroid follicular cells. Pax8 / mice are, therefore, completely athyroid in postnatal life and die around weaning unless they are substituted with thyroid hormones. As reported recently, Pax8 / mice can… (More)

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