Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage.

@article{Virmani2005AtheroscleroticPP,
  title={Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage.},
  author={Renu Virmani and Frank D Kolodgie and Allen P. Burke and Aloke Virmani Finn and Herman Kalman Gold and Thomas N. Tulenko and Steven P. Wrenn and Jagat S. Narula},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 10},
  pages={2054-61}
}
Observational studies of necrotic core progression identify intraplaque hemorrhage as a critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of erythrocyte membranes causes an abrupt change in plaque substrate characterized by increased free cholesterol within the lipid core and excessive macrophage infiltration. Neoangiogenesis is associated closely with plaque progression, and microvascular incompetence is a likely source of intraplaque hemorrhage… CONTINUE READING
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