Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan.

@article{Smith2006AtherosclerosisSL,
  title={Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan.},
  author={Jonathan D Smith and Jeffrey M. Bhasin and Julie Baglione and Megan Settle and Yaomin Xu and J. Barnard},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 3},
  pages={597-603}
}
OBJECTIVE Apolipoprotein (apo) E-deficient mice are hypercholesterolemic and develop atherosclerosis on low-fat chow diets; however, the genetic background strain has a large effect on atherosclerosis susceptibility. This study aimed to determine the genetic regions associated with strain effects on lesion area. METHODS AND RESULTS We performed a strain intercross between atherosclerosis sensitive DBA/2 and atherosclerosis resistant AKR apoE-deficient mice. Aortic root lesion area, total… CONTINUE READING
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Quantitative trait locus mapping for atherosclerosis susceptibility

JD Smith
Curr Opin Lipidol • 2003
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