Atherosclerosis is a vascular stem cell disease caused by insulin.

@article{Traunmller2018AtherosclerosisIA,
  title={Atherosclerosis is a vascular stem cell disease caused by insulin.},
  author={Friederike Traunm{\"u}ller},
  journal={Medical hypotheses},
  year={2018},
  volume={116},
  pages={
          22-27
        }
}
The present article proposes the hypothesis that when multipotent vascular stem cells are exposed to excessive insulin in a rhythmic pattern of sharply rising and falling concentrations, their differentiation is misdirected toward adipogenic and osteogenic cell lineages. This results in plaque-like accumulation of adipocytes with fat and cholesterol deposition from adipocyte debris, and osteogenic (progenitor) cells with a calcified matrix in advanced lesions. The ingrowth of capillaries and… CONTINUE READING
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