Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

  title={Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.},
  author={Dean A. Cox and Joseph A. Vita and Charles B. Treasure and Russell D. Fish and Robert W. Alexander and Peter A Ganz and Andrew P Selwyn},
  volume={80 3},
Studies in animals have suggested that increases in blood flow result in dilation of large arteries by an endothelium-dependent mechanism. Atherosclerosis can impair endothelium-dependent vasodilation to vasoactive agents. The purpose of this study was to determine whether or not large coronary arteries in humans exhibit dilation with increases in blood flow and to test the hypothesis that this response is impaired in the presence of atherosclerosis. Graded concentrations of adenosine were… CONTINUE READING