Atherogenesis and the arginine hypothesis.

  title={Atherogenesis and the arginine hypothesis.},
  author={John P Cooke and Roberta K Oka},
  journal={Current atherosclerosis reports},
  volume={3 3},
In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy. 

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