Atherogenesis and iron: from epidemiology to cellular level

@inproceedings{Vinchi2014AtherogenesisAI,
  title={Atherogenesis and iron: from epidemiology to cellular level},
  author={Francesca Vinchi and Martina U. Muckenthaler and Milene Ribeiro da Silva and Gy{\"o}rgy Balla and J{\'o}zsef Balla and Vikt{\'o}ria Jeney},
  booktitle={Front. Pharmacol.},
  year={2014}
}
Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a downstream consequence of the atheroma formation has been an open question for decades. According to the so called "iron hypothesis," iron is believed to be detrimental for the cardiovascular system, thus promoting atherosclerosis development and progression. Iron, in its catalytically active form, can participate in the generation of reactive oxygen species and induce lipid-peroxidation, triggering… CONTINUE READING
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