Atherogenesis and autoimmune disease: the model of lupus.

  title={Atherogenesis and autoimmune disease: the model of lupus.},
  author={Ian N. Bruce},
  volume={14 9},
Accelerated atherosclerosis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Certain 'classic' risk factors are associated with atherosclerosis risk in SLE. However, these factors alone do not fully explain the excess risk observed. Atherosclerosis is increasingly recognized as a chronic inflammatory condition and in SLE, complement activation and immune complex formation may promote atheroma development. Similarly, autoantibody production… CONTINUE READING


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