Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photodynamic therapy.

@article{Xue2010Atg7DI,
  title={Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photodynamic therapy.},
  author={Liang-yan Xue and Song-mao Chiu and Nancy Oleinick},
  journal={Autophagy},
  year={2010},
  volume={6 2},
  pages={248-55}
}
Photodynamic therapy (PDT) uses a photosensitizer, light and oxygen to produce extensive oxidative damage to organelles housing the photosensitizer. Although PDT is an efficient trigger of apoptosis, it also induces autophagy in many kinds of cells. Autophagy can serve as both a cell survival and a cell death mechanism. Our previous study indicates that autophagy contributes to cell death after PDT, especially in apoptosis-deficient cells. Here, we provide further evidence to support the role… CONTINUE READING

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