Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.

  title={Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.},
  author={Xiaoqi Xie and Ju Yong Koh and Sandy Price and E. P. White and Janice M Mehnert},
  journal={Cancer discovery},
  volume={5 4},
UNLABELLED Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous tumors, including melanoma. We utilized a genetically engineered mouse model of melanoma driven by oncogenic BrafV600E and deficiency in the Pten tumor suppressor gene in melanocytes to test the functional consequences of loss of the essential autophagy gene autophagy-related-7, Atg7. Atg7 deficiency prevented melanoma development by BrafV600E and allelic Pten loss, indicating that autophagy is… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 27 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

Autophagy inhibition improves chemosensitivity in BRAF ( V 600 E ) brain tumors

  • QW Fan, WA Weiss
  • Cancer Discov
  • 2014

Cancer statistics ,

  • R Siegel, J Ma, Z Zou
  • 2014

Similar Papers

Loading similar papers…