Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.

@article{Strmhaug2004Atg21IA,
  title={Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.},
  author={Per E Str\omhaug and Fulvio Reggiori and Ju Guan and C Wang and Daniel J Klionsky},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 8},
  pages={
          3553-66
        }
}
Delivery of proteins and organelles to the vacuole by autophagy and the cytoplasm to vacuole targeting (Cvt) pathway involves novel rearrangements of membrane resulting in the formation of vesicles that fuse with the vacuole. The mechanism of vesicle formation and the origin of the membrane are complex issues still to be resolved. Atg18 and Atg21 are proteins essential to vesicle formation and together with Ygr223c form a novel family of phosphoinositide binding proteins that are associated… CONTINUE READING

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