Atg2 mediates direct lipid transfer between membranes for autophagosome formation.

@inproceedings{Osawa2019Atg2MD,
  title={Atg2 mediates direct lipid transfer between membranes for autophagosome formation.},
  author={Takuo Osawa and Tetsuya Kotani and Tatsuya Kawaoka and Eri Hirata and Kuninori Suzuki and Hitoshi Nakatogawa and Yoshinori Ohsumi and Nobuo N Noda},
  year={2019}
}
A key event in autophagy is autophagosome formation, whereby the newly synthesized isolation membrane (IM) expands to form a complete autophagosome using endomembrane-derived lipids. Atg2 physically links the edge of the expanding IM with the endoplasmic reticulum (ER), a role that is essential for autophagosome formation. However, the molecular function of Atg2 during ER–IM contact remains unclear, as does the mechanism of lipid delivery to the IM. Here we show that the conserved amino… CONTINUE READING