Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.

@article{Yin2015AtenololRS,
  title={Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins.},
  author={Jia Yin and Haichuan Duan and Yoshiyuki Shirasaka and Bhagwat Prasad and Joanne H. Wang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 12},
  pages={
          1872-81
        }
}
Atenolol is a β-blocker widely used in the treatment of hypertension. Atenolol is cleared predominantly by the kidney by both glomerular filtration and active secretion, but the molecular mechanisms involved in its renal secretion are unclear. Using a panel of human embryonic kidney cell lines stably expressing human organic cation transporter (hOCT) 1-3, human organic anion transporter (hOAT) 1, hOAT3, human multidrug and toxin extrusion protein (hMATE) 1, and hMATE2-K, we found that atenolol… CONTINUE READING

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