Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.

@article{Nonhoff2007Ataxin2IW,
  title={Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.},
  author={Ute Nonhoff and Markus Ralser and Franziska Welzel and Ilaria Piccini and Daniela Balzereit and Marie-Laure Yaspo and Hans Lehrach and Sylvia Krobitsch},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 4},
  pages={
          1385-96
        }
}
Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous human diseases. The neurodegenerative disorder spinocerebellar ataxia type 2 is caused by a trinucleotide expansion in the SCA2 gene encoding a lengthened polyglutamine stretch in the gene product ataxin-2, which seems to be implicated in cellular RNA-processing pathways and translational regulation. Here, we substantiate a function of ataxin-2 in such pathways by… CONTINUE READING
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Here , we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD / H - box RNA helicase DDX6 , a component of P - bodies and stress granules , representing cellular structures of mRNA triage .
Ataxin-2 interacts with the DEAD / H - box RNA helicase DDX6 and interferes with P - bodies and stress granules .
Ataxin-2 interacts with the DEAD / H - box RNA helicase DDX6 and interferes with P - bodies and stress granules .
Here , we substantiate a function of ataxin-2 in such pathways by demonstrating that ataxin-2 interacts with the DEAD / H - box RNA helicase DDX6 , a component of P - bodies and stress granules , representing cellular structures of mRNA triage .
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