Ataxin-2 associates with rough endoplasmic reticulum.

  title={Ataxin-2 associates with rough endoplasmic reticulum.},
  author={Simone van de Loo and Florian Eich and David Nonis and Georg Auburger and Joachim Nowock},
  journal={Experimental neurology},
  volume={215 1},
Ataxin-2 is a novel protein, normally with a domain of 22 consecutive glutamine (Q) residues, which may expand beyond a threshold of (Q)(32), causing a neurodegenerative disease named Spinocerebellar ataxia type 2 (SCA2). To obtain clues about the functions of ataxin-2, we used fluorescence microscopy and centrifugation fractionation analyses. Immunocytochemical detection in non-neuronal and neuronal cells showed endogenous and transfected ataxin-2 distributed throughout the cytoplasm, with… CONTINUE READING
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