Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling

@inproceedings{Drost2012Ataxin2MT,
  title={Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling},
  author={Jessica Drost and David Nonis and Florian Eich and Oliver Leske and Ewa Damrath and Ewout R. P. Brunt and Isabel Lastres-Becker and Rolf Heumann and Joachim Nowock and Georg Auburger},
  booktitle={Journal of Molecular Neuroscience},
  year={2012}
}
Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain of function of ATXN2 leads to neuronal atrophy in the diseases spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS). Conversely, ATXN2 knockout (KO) mice show hypertrophy and insulin resistance. To elucidate the influence of… CONTINUE READING