Ataxin-2, global regulators and bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain

@article{Neuwald1998Ataxin2GR,
  title={Ataxin-2, global regulators and bacterial gene expression, and spliceosomal snRNP proteins share a conserved domain},
  author={Andrew F. Neuwald and Eugene V. Koonin},
  journal={Journal of Molecular Medicine},
  year={1998},
  volume={76},
  pages={3-5}
}
The primary cause of hereditary ataxias and several other neurological diseases is the expansion of CAG trinucleotide repeats in the respective disease-associated gene, resulting in polyglutamine stretches in the expressed proteins [1]. The genes involved are unrelated to each other, and in most of the cases there is no indication of their function. The recently cloned gene for spinocerebral ataxia 2 (SCA2) encodes a 140-kDa protein (ataxin-2) with no reported imilarity to functionally… CONTINUE READING
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