Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4

@inproceedings{Pfeiffer2017Ataxin3CT,
  title={Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4},
  author={Annika Pfeiffer and Martijn S. Luijsterburg and Kl{\`a}ra {\'A}cs and Wouter W. Wiegant and Angela Helfricht and Laura K Herzog and Melania Minoia and Claudia B{\"o}ttcher and Florian A. Salomons and Haico van Attikum and Nico P Dantuma},
  booktitle={The EMBO journal},
  year={2017}
}
The SUMO-targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin-3 counteracts RNF4 activity during the DNA double-strand break (DSB) response. We find that ataxin-3 negatively regulates ubiquitylation of the checkpoint mediator MDC1, a known RNF4 substrate. Loss of ataxin-3 markedly decreases the chromatin dwell time of MDC1 at DSBs, which can be fully reversed by co-depletion of RNF4. Ataxin-3… CONTINUE READING

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