Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

@article{Zha2011AtaxiaTP,
  title={Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.},
  author={Shan Zha and Wenxia Jiang and Yuko Fujiwara and Harin Patel and Peter H. Goff and James W. Brush and R. Luke DuBois and Frederick W Alt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 5},
  pages={2028-33}
}
Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each germ-line gene segment is flanked by recombination signal sequences (RSs). Recombination-activating gene endonuclease initiates V(D)J recombination by cleaving a pair of gene segments at their junction with flanking RSs to generate covalently sealed (hairpinned) coding ends (CEs) and blunt 5'-phosphorylated RS ends (SEs). Subsequently… CONTINUE READING

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H 2 AX prevents CtIP - mediated DNA end resection and aberrant repair in G 1 - phase lymphocytes

BA Helmink
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