Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.

@article{Sordet2009AtaxiaTM,
  title={Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.},
  author={Olivier Sordet and Christophe E. Redon and Jos{\'e}e Guirouilh-Barbat and Susan Smith and St{\'e}phanie Solier and C{\'e}line Douarre and Chiara Conti and Asako J. Nakamura and Benu Brata Das and Estelle Nicolas and Kurt W. Kohn and W. M. Bonner and Yves Pommier},
  journal={EMBO reports},
  year={2009},
  volume={10 8},
  pages={
          887-93
        }
}
Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent transcription-blocking lesions-also produce transcription-dependent DNA double-strand breaks (DSBs) with ATM activation. We show the induction of DSBs and DDR activation in post… CONTINUE READING
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